The determination of the soul weighing 21 grams was based on the average loss of mass in the six patients. Nonetheless, Mac Dougall's finding that the human soul weighed 21 Grams has become a meme in the public consciousness, mostly due to its claiming the titular thesis in the 2003 film 21 Grams.
The broad biological activities of hydroxamates and the need to improve on their synthetic routes informed the review of their synthesis and biological applications. 5, 6 A number of synthetic routes are available for the preparation of hydroxamic acids, 7-12 but some are tedious, time consuming and costly as well. Colombo, An improved synthesis of the HDAC inhibitorn trichostatin A, Master s Theses and Doctoral Dissertations, Eastern Michigan University, 2009, 1-2.